Melrose is a mostly residential neighborhood in the southwestern section of the New York City borough of the Bronx. It adjoins the business and one-time theater area known as The Hub. Melrose is rectangular-shaped, being bordered by Third Avenue on the east, 149th Street on the south, Park Avenue on the west and 161st Street to the north. Melrose Avenue and Third Avenue are the primary thoroughfares through Melrose.

Predominantly German-American in the 19th century it was home to Haffen Brewing Company. The German population waned especially post-World War II. The neighborhood until the 1960s was mostly Irish and Italian.^[4] It is now primarily Latino.

Grupo TACA operates a Bronx-area TACA Satellite at 570 Melrose Avenue.^[5] Melrose is considered part of the socioeconomic South Bronx.