SoHo, sometimes written Soho  is a neighborhood in Lower Manhattan in New York City. Since the 20th century it has been the location of many artists' lofts and art galleries, and has also been known for its variety of shops ranging from trendy upscale boutiques to national and international chain store outlets. The area's history is an archetypal example of inner-city regeneration and gentrification, encompassing socioeconomic, cultural, political, and architectural developments.

The name "SoHo" derives from the area being "South of Houston Street", and was coined in 1962 by Chester Rapkin, an urban planner and author of The South Houston Industrial Area study, also known as the "Rapkin Report". The name also recalls Soho, an area in London's West End. 

Almost all of SoHo is included in the SoHo–Cast Iron Historic District, which was designated by the New York City Landmarks Preservation Commission in 1973, extended in 2010, and was listed on the National Register of Historic Places and declared a National Historic Landmark in 1978. It consists of 26 blocks and approximately 500 buildings, many of them incorporating cast-iron architectural elements. Many side streets in the district are paved with Belgian blocks. 

The SoHo–Cast Iron Historic District is contained within the zoned SoHo neighborhood. Originally ending in the west at the eastern side of West Broadway and to the east at the western side of Crosby Street, the SoHo–Cast Iron Historic District was expanded in 2010 to cover most of West Broadway and to extend east to Lafayette and Centre Streets. The boundary lines are not straight, and some block-fronts on West Broadway and Lafayette are excluded from the District. 

SoHo can be reached by the New York City Subway, using the A, ​C, and ​E trains to Spring Street; 1 and ​2 trains to Houston Street; the N, ​Q, ​R, and ​W trains to Prince Street; and the 4, ​6, and <6>trains to Spring Street. The crosstown M21 on Houston Street and the north-south M1, M55 bus routes also serve the neighborhood.